Early test results reduce maternal anxiety
News release from the National Coordinating Centre for Health Technology Assessment
22 January 2007
New research published by the NIHR Health Technology Assessment (HTA) programme suggests that providing early results from a partial but rapid test helps to reduce the anxiety pregnant women feel while waiting for the full results of amniocentesis.
Amniocentesis, where a sample of amniotic fluid is drawn, is the most common prenatal diagnostic procedure undertaken in the UK , providing an important way of finding out whether a baby may be affected by a chromosomal abnormality such as Down's Syndrome, while inside the womb. Following amniocentesis, the cells that have been obtained are cultured for two-four weeks before undergoing a full karyotype analysis. The more rapid tests (FISH and PCR) can be done before the cells are cultured, with results in three or four days, but these only detect the most common structural chromosomal abnormalities.
The ARIA trial, led by Professor Jenny Hewison of the University of Leeds , involved 226 women across 12 hospitals in England . The research team aimed to find out whether issuing early partial results from the rapid tests alters maternal anxiety during the waiting period following amniocentesis, compared with waiting until full results are available. The team also investigated whether giving results out on a fixed date altered the level of anxiety patients felt during the waiting period compared with a policy of telling them that the result would be issued as soon as available.
Researchers found that women who received early results were significantly less anxious while waiting for their full test results than women who had not. There was no evidence that giving out results on a fixed or on a variable date altered maternal anxiety during the waiting period.
“Many pregnant women experience anxiety while waiting for the results of diagnostic tests, particularly amniocentesis tests for Down's syndrome, but little research has been carried out into the best policies and practices for reducing this anxiety,” says Professor Hewison. “Our research suggests that rapid testing may be beneficial when offered to women in addition to karyotyping. Since there are no clear advantages of issuing results as soon as they become available rather than on a fixed date, women could be given a choice.”
This research is published in the Health Technology Assessment journal series Vol 10.50. To download the full report visit http://www.hta.ac.uk/project/1211.asp
Notes for editors
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The HTA programme is a programme of the National Institute for Health Research (NIHR) and produces high quality research information about the effectiveness, costs, and broader impact of health technologies for those who use, manage and provide care in the NHS. It is the largest of the NIHR programmes and publishes the results of its research in the Health Technology Assessment journal, with more than 400 issues published to date. The journal’s 2007 Impact Factor (3.87) ranked it in the top 10% of medical and health-related journals. All issues are available for download free of charge from the website, www.hta.ac.uk The HTA programme is coordinated by the National Coordinating Centre for Health Technology Assessment (NCCHTA), based at the University of Southampton.
- The National Institute for Health Research provides the framework through which the research staff and research infrastructure of the NHS in England is positioned, maintained and managed as a national research facility. The NIHR provides the NHS with the support and infrastructure it needs to conduct first-class research funded by the Government and its partners alongside high-quality patient care, education and training. Its aim is to support outstanding individuals (both leaders and collaborators), working in world class facilities (both NHS and university), conducting leading edge research focused on the needs of patients. www.nihr.ac.uk
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