Details of HTA journal title
Last updated: 15 July 2008 - Next update due: 22 July 2008
Research type: |
Primary Research (e.g. trial) |
Title (lead author) etc: |
A randomised controlled trial of cognitive behaviour therapy in adolescents with major depression treated by selective serotonin reuptake inhibitors. The ADAPT trial (Goodyer) 80 pages, Volume 12, number 14 |
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Outputs in journals arising from this project
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Headline: |
Study finds that for moderately to severely depressed adolescents who are non-responsive to a brief initial psychosocial intervention, the addition of cognitive behaviour therapy to fluoxetine given in the context of routine clinical care in a specialist mental health services environment does not improve outcome or confer protective effects against adverse events and is not cost-effective. |
Project ref: |
97/29/01 |
Original project title: |
Randomised trial of fluoxetine and cognitive-behavioural therapy versus fluoxetine alone in adolescents with persistent major depression |
Chief Investigator: |
Professor J.F.W. Deakin, Professor of Adult Psychiatry, Psychiatry, University of Manchester |
Start Date: |
September 2000. |
Publication date: |
May 2008 |
Cost: |
£463,360 |
MeSH* index primary terms: |
DEPRESSION Q-therapy; FLUOXETINE Q-therapeutic-use; COGNITIVE-THERAPY Q-economics (* = Medical Subject Headings) |
MeSH* index secondary terms: |
HUMAN; ADOLESCENCE; CLINICAL-TRIAL; RANDOMIZED-CONTROLLED-TRIAL; ANTIDEPRESSIVE-AGENTS Q-therapeutic-use; QUALITY-OF-LIFE; COSTS-AND-COST-ANALYSIS; COST-BENEFIT-ANALYSIS; TREATMENT-OUTCOME (* = Medical Subject Headings) |
ISRCTN* number: | ISRCTN 83809224 (*International Standard Randomised Controlled Trial Number) URL of this project on the Controlled Trials Website: http://www.controlled-trials.com/ISRCTN83809224 |
NRR* number, if applicable: |
N0484056614 (*National Research Register) |
Project Protocol: |
Project protocol not available |
Printed copies of this title despatched: |
114 (Figures relate to the previous calendar month) |
Downloads/Views of electronic version from website: |
1838 (Figures are cumulative.) Last updated 8th July 2008. |
URL of this page: |
http://www.hta.ac.uk/1123 |
Outputs from this project
- Harrington, RC; Cartwright-Hatton, S; Stein, A. Randomised Trials. Journal of Child Psychology and Psychiatry Vol 43; 6 pages 695-704.
- Harrington, R; Dubicka, B. Adolescent depression: an evidence-based approach to intervention. Current Opinion in Psychiatry.
- Harrington, R; Goodyer, I; Breen, S; Barrett, B; Byford, S; Dubicka, B; Ford, C; Kelvin, R; Leech, A; Roberts, C; Rothwell, J; Wilkinson, P; White, L. Adolescent Depression Antidepressant & Psycotherapy Trial. - A Randomised Controlled Trial of SSRIs with and without cognitive behaviour therapy in adolescents with major depression. BMJ.
- Goodyer, I; Dubicka, B; Wilkinson, P; Kelvin, R; Roberts, C; Byford, S; Breen, S; Ford, C; Barrett, B; Leech, A; Rothwell, J; White, L; Harrington, R. Selective serotonin reuptake inhibitors (SSRIs) and routine specialist care with and without cogitive behaviour therapy in adolescents with major depression: randomised controlled trial. BMJ. 2007 Jul 21;335(7611):142. Epub 2007 Jun 7.
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