Details of HTA journal title
Last updated: 15 July 2008 - Next update due: 22 July 2008
Research type: |
Primary Research (e.g. trial) |
Title (lead author) etc: |
Topical or oral ibuprofen for chronic knee pain in older people. The TOIB study (Underwood) 176 pages, Volume 12, number 22 |
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Headline: |
Study on whether GPs should advise their older patients with chronic knee pain to use topical or oral non-steroidal anti-inflammatory drugs (NSAIDs) found that oral NSAIDs appear to produce more minor adverse effects than topical NSAIDs. |
Project ref: |
01/09/02 |
Original project title: |
Are topical or oral Ibuprofen equally effective for the treatment of chronic knee pain in older people (Topical or Oral Ibuprofen TOIB) |
Chief Investigator: |
Professor Martin Underwood, Vice-Dean, Health Sciences Research Institute, Warwick Medical School, University of Warwick |
Start Date: |
July 2002. |
Publication date: |
May 2008 |
Cost: |
£725,617 |
MeSH* index primary terms: |
ARTHRALGIA Q-drug-therapy; IBUPROFEN Q-therapeutic-use; ANALGESICS-NON-NARCOTIC (* = Medical Subject Headings) |
MeSH* index secondary terms: |
HUMAN; RANDOMIZED-CONTROLLED-TRIAL; CLINICAL-TRIAL; QUESTIONNAIRES; KIDNEY Q-physiology; HEMOGLOBINS Q-analysis; FERRITIN Q-analysis; BLOOD-PRESSURE; LUNG Q-physiology (* = Medical Subject Headings) |
ISRCTN* number: | ISRCTN 79353052 (*International Standard Randomised Controlled Trial Number) URL of this project on the Controlled Trials Website: http://www.controlled-trials.com/ISRCTN79353052 |
NRR* number, if applicable: |
N0484112114 (*National Research Register) |
Project Protocol: |
Project protocol (pdf format, 171 kbytes) |
Printed copies of this title despatched: |
116 (Figures relate to the previous calendar month) |
Downloads/Views of electronic version from website: |
1771 (Figures are cumulative.) Last updated 8th July 2008. |
URL of this page: |
http://www.hta.ac.uk/1302 |
Outputs from this project
- Carnes, D; Anwer, Y; Harding, G; Underwood, M; Parsons, S. Influcences on older people'd decision-making regarding choice of topical or oral NSAIDs for their knee pain: A qualitative study nested in a randomised controlled trial and a patient preference study, data from topical or oral ibuprofen (TOIB) study. BMJ (accepted for publication).
- Underwood, M; Ashby, D; Cross, P; Hennessy, E; Letley, L; Martin, J; Mt-Isa, S; Parsons, S; Vickers, M; Whyte, K. Advice to use topical or oral ibuprofen for chronic knee pain in older people: a radomised cintrolled trial and patient preference study: The TOIB study. BMJ (accepted for publiaction).





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